Slide 92.Papillary carcinoma, Thyroid

A. Brief Descriptions

  1. Most common form of thyroid cancer.

  2. Twenties to forties, associated with previous exposure to ionizing radiation.

B. Gross Findings

  1. Solid, firm, grayish white lobulated lesion with sclerotic center.

C. Micro Findings

  1. Based on characteristic architecture & cytological feature.

  2. Papillae formed by a central fibrovascular stalk & covered by neoplastic epithelial cells.

  3. Psammoma bodies in the papillary stalk, fibrous stroma or between tumor cells.

  4. Nuclear features:

    • Round to slight oval shape.

    • Pale, clear, empty or ground glass appearance (Orphan Annie): empty of nucleus with irregular thickened inner aspect of nuclear membrane.

    • Pseudo-inclusion: deep cytoplasmic invagination and result in nuclear acidophilic, inclusion-like round structures, sharply outlined and eccentric, with a crescent-shaped rim of compressed chromatin on the side.

    • Grooves: coffee-bean like.

D. Others:

  1. The most common form of differentiated thyroid carcinoma.

E. Reference

  1. Robbins Pathologic Basis of Disease, 6th ed.  P.1143.




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