《Slide 124.》Rapidly progressive glomerulonephritis (RPGN),
 Kidney

A. Brief Descriptions：

1. A syndrome associated with severe glomerular injury and does not denote a specific etiologic form of glomrulonephritis.

2. Loss of renal function associated with severe oliguria and death from renal failure within week to months.

B. Gross Findings：

1. The kidney is enlarged and pale, often with petechial hemorrhages on the cortical surfaces.

C. Micro Findings：

1.  Diffuse crescentic glomerulonephritis.

2. Massive proliferation of cells (crescent formation) in Bowman's space, affecting a high percentage of glomeruli, & quickly develop renal failure.

3. Glomeruli:

   • Crescent on the inside of Bowman's capsule, from a focal & segmental accumulation of a few cells lining Bowman's capsule to extensively circumferential involvement.

   • Cellular, fibrocellular or fibrotic crescent.

   • Minimal change in tuft & tubules in early stage, then tubular atrophy, fibrosis & scarring in progressive patient.

   • Edematous interstitium with mononuclear cells infiltration.

D. Others:

   略.

E. Reference：

1. Robbins Pathologic Basis of Disease, 6^th ed.  p.951-952

　

 

 

【 Fig. 124-1 (20X)】Degenerated and regenerated tubules.Note edematous stroma.

　

 

 

【 Fig. 124-2 (10X)】Hemorrhagic and chronic inflamed stroma.

　

 

 

【 Fig. 124-3 (20X)】Hyaline casts in renal tubules.

　

 

 

【 Fig. 124-4 (20X)】Crescent on the inside of Bowman's capsule.

　

 

 

【 Fig. 124-5 (20X)】Crescent on the inside of Bowman's capsule.

　

 

 

【 Fig. 124-6 (20X)】Crescent on the inside of Bowman's capsule.

　

 

 

【 Fig. 124-7 (40X)】Crescent on the inside of Bowman's capsule.

　

 

 

【 Fig. 124-8 (20X)】Crescent on the inside of Bowman's capsule.

　

 

 

【 Fig. 124-9 (40X)】Crescent on the inside of Bowman's capsule.

　

 

 

【 Fig. 124-10 (40X)】Some glomerulus demonstrates sclerosing change.

　

 

 

【 Fig. 124-11 (40X)】Some glomerulus undergoes sclerosing change.