《Slide 163.》Germinoma, Pineal gland

A. Brief Descriptions：

1. Germ cell neoplasm identical to those in the gonad and mediastinum.

2. Strong male predominance.

B. Gross Findings：

     略.

C. Micro Findings：

1. Sheets， lobules，and nests of large round neoplastic cells interspersed with lymphocytes & delicate septae of fibrous tissue.

2. Round vesicular nuclei with prominent nucleoli.

3. Indistinct、somewhat vacuolated、pale、 glycogen-rich cytoplasm.

4. Variable amounts of associated T-lymphocytes infiltrates.

5. Granuloma and syncytiotrophoblastic giant cells might be seen in some cases.

D. Others:

1. 此片的病理變化與發生於testis的seminoma是相同的。Sheets， lobules，and nests of large round neoplastic cells interspersed with lymphocytes是典型的特色。

2. Primary germ cell tumor好發於adolescents和young adults。Tumor 以midline發生位置最多見，尤其是pineal and suprasellar regions蠻常見。發生於pineal area的germ cell tumor以男性居多，而且不發生於suprasellar region。

E. Reference：

1. Robbins Pathologic Basis of Disease, 6^th ed.  P.1350.

【 Fig. 163-1 (LP)】Relatively well-defined tumor destructed pineal gland and extending into recessus pinealis.

【 Fig. 163-2 (LP)】

【 Fig. 163-3 (LP)】Infiltrated individual cells with fibrous septi, noted lymphocytes in fibrous septi.

【 Fig. 163-4 (LP)】Tumor cells with abundant clear cytoplasm, large nuclei and prominent (red) nucleoli.