《Slide 196.》Malignant meningioma, Meninges

A. Brief Descriptions：

1. Correspond to WHO grade III.

2. Increased tendency of recurrence and locally aggressive behavior.

3. Usually fatal, with median survivals of less than 2 years.

B. Gross Findings：

     略.

C. Micro Findings：

1. Obvious cytological malignancy (similar to sarcoma, carcinoma or melanoma).

2. High mitotic index: >20 mitoses / 10 HPF.

3. Multifocal microscopic foci of necrosis and loss of usual growth patterns.

D. Others:

     略.

E. Reference：

1. Robbins Pathologic Basis of Disease, 6^th ed.  P.1350-1351.

　

 

 

【 Fig. 196-1 (LP)】

　

　

 

【 Fig. 196-2 (LP)】May invade bone.

　

 

 

【 Fig. 196-3 (LP)】Marked cellullarity.

　

 

【 Fig. 196-4 (LP)】Necrosis.

　

　

 

【 Fig. 196-5 (LP)】Numerous mitotic figures.

　

 

 

【 Fig. 196-6 (HP)】Nuclear anaplasia.

　

 

 

【 Fig. 196-7 (HP)】