Slide 148.Molluscum contagiosum, Skin

A. Brief Descriptions

  1. Common, self-limited viral disease of the skin caused by a poxvirus.

  2. Multiple lesions with a predilection for the truck and anogenital area.

  3. Firm, puritic, pink to skin-colored umbilicated papules.

 B. Gross Findings

  1. Waxy pink or skin-colored, firm, prutic papules with umbilicated center

C. Micro Findings

  1. Epithelial hyperplasia with epidermal growth downward in lobules.

  2. Many epidermal cells contain large intracytoplasmic inclusion bodies, the so-called molluscum bodies.

  3. The molluscum bodies grow in size as they move toward the surface.

  4.  In the horny layer, numerous large, basophilic molluscum bodies lie enmeshed in a network of eosinophilic horny fibers.

  5.  In the center of the lesion, the stratum corneum ultimately disintegrates, releasing the molluscum bodies and forming a central crater.

  6. The surrounding dermis shows little or no inflammatory reaction.

D. Others

1.             Viral disease of the skin (Poxvirus)

2.             Age: children & young adults; esp. males

3.             Predilection site: trunk and anogenital areas

E. Reference




Fig. 148-1 (4X)




Fig. 148-2 (10X)




Fig. 148-3 (20X)