《Slide 150.》Liposarcoma, Soft tissue
　

A. Brief Descriptions：

1. One of the most common soft tissue sarcoma of adulthood.

   2.    A peak incidence between 40 and 60 years, with two major sites in the extremities (thigh) and the
          retroperitoneum.

B. Gross Findings：

1. Tend to be well circumscribed or encapsulated with a lobulated pattern and satellite nodules.

C. Micro Findings：

1. Five basic histological categories:

   1. Myxoid liposarcoma.

   2. Round cell liposarcoma.

   3. Well-differentiated liposarcoma (including atypical lipoma).

   4. Dedifferentiated liposarcoma.

   5. Pleomorphic liposarcoma.

2. In our slide:

   1. An extreme degree of cellular pleomorphism with different differentiated stages of lipoblasts and some bizarre multinucleated tumor giant cells.

   2. Lipoblast: hyperchromatic, scalloped nuclei with prominent nucleoli and different content of intracellular lipid material.

   3. Mitosis is easily seen.

   4. Areas of myxoid change are also noticed.

D. Others:

     略.

E. Reference：

1. Robbins Pathologic Basis of Disease, 6^th ed.  P1261.

　

　

 

【 Fig. 150-1 (LP)】 Hypercellular tumor with focal myxoid change (center).

　

 

 

【 Fig. 150-2 (LP)】

　

　

 

【 Fig. 150-3 (LP)】 Extreme degree of cellular pleomorphism with different differentiated stages of lipoblasts.

　

 

【 Fig. 150-4 (HP)】 Lipoblasts with hyperchromatic, scalloped nuclei which were pushed by intracytoplasmic fatty vacuoles.