《Slide 152.》Chondrosarcoma, dedifferentiated, Rib
　

A. Brief Descriptions：

1. A biphasic tumor consisting of a poorly differentiated sarcomatous component juxtaposed to an otherwise typical low-grade chondrosarcoma.

2. Peak age: sixth decade with most common lesions in femur and pelvis.

3. Radiographic features: an aggressive area superimposed on typical chondrosarcoma.

B. Gross Findings：

1. Lobulated, gray-white hyaline cartilage coexists with a well circumscribed soft tumor mass.

C. Micro Findings：

1. Lobulated, hyaline cartilaginous lesion.

2. Cellular lesion (chondrocytes) with pleomorphic, hyperchromatic or binucleated nuclei cells.

D. Others:

   略.

E. Reference：

1. Robbins Pathologic Basis of Disease, 6^th ed.  P1240-1242.

　

 

 

【 Fig. 152-1 (LP)】 Hyaline cartilaginous lesion (lower) surrounded by spindle cells (right upper).

 

【 Fig. 152-2 (LP)】 Chondroid lesions surrounded by small blue cells with hyperchromatic nuclei.
　

 

 

【 Fig. 152-3 (LP)】 Crowed chondrocytes with pleomorphic, hyperchromatic or binucleated nuclei pattern.

　

 

【 Fig. 152-4 (HP)】(Upper) chondrocytes with pleomorphic, hyperchromatic or binucleated nuclei pattern. (Lower) Spindle cell stroma showed marked cellular atypia with atypical mitotic figures.