《Slide 3.》Necrosis of cerebellum, Cerebellum

A. Brief Descriptions：

1. Encephalomalacia: necrosis of the brain following by liquefaction & secondary cavitation.

2. Stages:

   • Cortical pallor with ischemic change in neurons.

   • Softening with granular foamy cells (Gitter cells).

   • Cystic formation & glial scarring.

C. Micro Findings：

1. Congestion, hemorrhage, or hemosiderin deposits.

2. Destruction of structure with heavy infiltration by neutrophils, lymphocytes....

3. Necrosis & granular foamy cells ( from phagocytic microglial cells, Gitter cells ).

4. Gitter cells: vacuolated, eosinphilic or granular cytoplasm with eccentrically located nuclei.

D. Reference：

1. Robbins Pathologic Basis of Disease, 6^th ed.  P.15-18.

 

　

 

 

【 Fig. 3-1 (LP)】The necrotic area (right half) is surrounded by granulation tissue in the left.

　

  

 

【 Fig. 3-2 (LP)】The granulation tissue is composed of regenerated vasculature, fibroblasts and inflammatory cells.

　

 

 

【 Fig. 3-3 (HP)】The necrotic area is composed of cell debris (pinkish color) and nuclear dusts (dark purple or blue color).