《Slide 3.》Necrosis of cerebellum, Cerebellum
A. Brief Descriptions：
Encephalomalacia: necrosis of the brain following by liquefaction & secondary cavitation.
Cortical pallor with ischemic change in neurons.
Softening with granular foamy cells (Gitter cells).
Cystic formation & glial scarring.
C. Micro Findings：
Congestion, hemorrhage, or hemosiderin deposits.
Destruction of structure with heavy infiltration by neutrophils, lymphocytes....
Necrosis & granular foamy cells ( from phagocytic microglial cells, Gitter cells ).
Gitter cells: vacuolated, eosinphilic or granular cytoplasm with eccentrically located nuclei.
Robbins Pathologic Basis of Disease, 6th ed. P.15-18.
【 Fig. 3-1 (LP)】The necrotic area (right half) is surrounded by granulation tissue in the left.
【 Fig. 3-2 (LP)】The granulation tissue is composed of regenerated vasculature, fibroblasts and inflammatory cells.
【 Fig. 3-3 (HP)】The necrotic area is composed of cell debris (pinkish color) and nuclear dusts (dark purple or blue color).