Slide 3.Necrosis of cerebellum, Cerebellum

A. Brief Descriptions

  1. Encephalomalacia: necrosis of the brain following by liquefaction & secondary cavitation.

  2. Stages:

    • Cortical pallor with ischemic change in neurons.

    • Softening with granular foamy cells (Gitter cells).

    • Cystic formation & glial scarring.

C. Micro Findings

  1. Congestion, hemorrhage, or hemosiderin deposits.

  2. Destruction of structure with heavy infiltration by neutrophils, lymphocytes....

  3. Necrosis & granular foamy cells ( from phagocytic microglial cells, Gitter cells ).

  4. Gitter cells: vacuolated, eosinphilic or granular cytoplasm with eccentrically located nuclei.

D. Reference

  1. Robbins Pathologic Basis of Disease, 6th ed.  P.15-18.





Fig. 3-1 (LP)The necrotic area (right half) is surrounded by granulation tissue in the left.




Fig. 3-2 (LP)The granulation tissue is composed of regenerated vasculature, fibroblasts and inflammatory cells.




Fig. 3-3 (HP)The necrotic area is composed of cell debris (pinkish color) and nuclear dusts (dark purple or blue color).