Slide 7.Fatty liver, Liver

A. Brief Descriptions

  1. Cause: alcoholic , obesity , non-alcoholic steatohepatitis….

  2. Abnormal accumulation of neutral triglyceride (fat) in hepatocytes , when severe may impair cellular function.

B. Gross Findings

  1. Mild fatty change: no gross change.

  2. Progressive change: enlarges and getting yellow.

  3. Severe: enlarge,pale or bright yellow,soft,greasy and may even weigh 3~6 kg.

C. Micro Findings

  1.  Many small globular intracytoplasmic clear space, may accumulate and displace the nucleus to the periphery.

  2. Contiguous cells may rupture to produce fatty cyst.

D. Others:

  1. 病理組織重點:

    • Fat vacuoles in the cytoplasm around the nucleus.

    • 特殊染色: prepare by frozen section and stained by Sudan III or Sudan black.

E. References

  1. Robbins Pathologic Basis of Disease, 6th ed.  P.39-40.




Fig. 7-1 (LP)




Fig. 7-2 (LP)




Fig. 7-3 (HP).




Fig. 7-4 (HP)




Fig. 7-5 (HP).