Slide 21.Postnecrotic Cirrhosis,  Liver

A. Brief Descriptions

  1. Cause : alcohol abuse , chronic hepatitis , biliary disease and iron overload.

  2. Progressive fibrosis of liver parenchyma.

  3. It is generally irreversible.

B. Gross Findings

  1. Macronodular cirrhosis with marked variation in size & shape of the nodules ( 3mm - 10mm or larger ).

C. Micro Findings

  1. Fibrosis, regenerated nodules & complete vascular/microanatomical distortion.

  2. Thick or thin fibrous septi with venous radicals, bile ducts, & arteries without normal portal tracts.

D. Others:

    1.   Classified by its etiology.

    2.   The end stages of almost any form of chronic active liver disease.

    3.   Def. of cirrhosis:

l A diffuse process characterized by fibrosis & a conversion of normal architecture into structurally abnormal nodules.

l    A chronic irreversible disease of liver in which the normal architecture is destroyed by deposition of connective tissue & regenerated nodules.

E. Reference

  1. Robbins Pathologic Basis of Disease, 6th ed.  P.853-855.




Fig. 21-1 (LP)




Fig. 21-2 (LP)




Fig. 21-3 (HP)