《Slide 177.》Squamous Cell Carcinoma , Esophagus

A. Brief Descriptions：

1. Occur in adults over age 50.

2. Male-female ratio: 2:1 to 20:1.

3. Risk factors: dietary, lifestyle, esophageal disorders, genetic predisposition.

B. Gross Findings：

1. Irregular ulcers with sharply demarcated nodular margins.

2. Grayish white cut surface.

C. Micro Findings：

1. Infiltration of cancer cell nests through whole layers.

2. Poorly demarcated cell nests from the surrounding stroma.

3. Well differentiated cells with intercellular bridge & keratin pearl formation & sheets of partially keratinized cells.

D. Others:

1. Compare with slides 27.

2. What is associated with prognosis？

E. Reference：

    Robbins Pathologic Basis of Disease, 6^th ed.  P.783-786.

　

 

 

【 Fig. 177-1 (2X)】Squamoid cancer cells invaded into muscular layer seen in this low power field.

　

 

 

【 Fig. 177-2 (4X)】Squamoid cancer cells grew from surface and invaded into muscular layer seen in this view.

　

　

【 Fig. 177-3 (4X)】Ulcerated squmaoid cancer cells grew into submuosa.

　

 

 

【 Fig. 177-4 (10X)】Squamoid cancer cells invaded into muscular layer.

　

 

 

【 Fig. 177-5 (10X)】Squamoid cancer cells with keratinizing.

　

 

 

【 Fig. 177-6 (20X)】Squamoid cancer cells with keratinizing.

　

 

 

 

【 Fig. 177-7 (40X)】Intercellular bridge seen in high power view.