《Slide 52.》Acute myocardial infarction, Heart

A. Brief Descriptions：

1.  sequential changes in myocardial infarction:

   　

   time	Gross features	light microscope
   1 ~ 4 hrs	none	none
   4 ~ 12 hrs	none	begin coagulative necrosis, neutrophil infiltrates ; edema, hemorrhage.
   18 ~ 24 hrs	pallor	continuing coagulation necrosis marginal contraction band necrosis
   24 ~ 72 hrs	pallor, sometimes hyperemia	loss of nuclei and striation heavy infiltration of neutrophils
   3 ~ 7 days	hyperemic border central yellow-brown	disintegration of dead myofibers macrophages present onset of marginal fibrovascular response
   10 days	red-brown & depressed yellow & soft vascularized margins	well-develop necrotic changes prominent fibrovascular reaction in margin
   7th weeks	scarring	fibrotic

   　

B. Gross Findings：

     略.

C. Micro Findings：

1. Necrosis of muscle bundles with densely inflammatory infiltrate; note pericarditis with fibrinopurulent exudate in the upper part of the picture.

2. Degenerated muscle bundles and densely inflammatory infiltration.

D. Others:

     略.

E. Reference：

1. Robbins Pathologic Basis of Disease, 6^th ed.  P.554-563.

　

 

【 Fig. 52-1 (LP)】Necrosis of muscle bundles with densely inflammatory infiltrate; note pericarditis with fibrinopurulent exudate in the upper part of the picture.

 

　

 

【 Fig. 52-2 (LP)】Degenerated muscle bundles and densely inflammatory infiltration.

　

　

 

【 Fig. 52-3 (HP)】