《Slide 75.》Condyloma acuminatum, Penis

A. Brief Descriptions：

1. Benign tumor caused by several types of human papillomavrus (HPV).

2. It is related to the common wart ( verruca vulgaris ) and may occur on any moist muco-cutaneous surface of the external genitals in either sex.

B. Gross Findings：

     Single or multiple sessile or pedunculated, red papillary excrescences that vary from 1 to several millimeters in diameter, occasionally coalesce into cauliflowerlike masses.

C. Micro Findings：

1. A branching , villous or papillary connective tissue stroma covered by a thickened hyperplastic epithelium.

2. The epithelium shows considerable superficial hyperkeratosis, parakeratosis and thickening of the underlying epidermis (acanthosis) with thickening and elongation of the rete ridges.

3. Distinct perinuclear clear vacuolization of the prickle cells (koilocytosis) as characteristic of HPV infection.

4. These vacuolated epithelial cells are relatively large and possess a hyperchromatic, round nucleus.

5. The basement membrane is intact without invasion of the underlying stroma.

6. The stroma (dermis) appears edematous with dilated capillaries and a moderately dense, chronic inflammatory infiltrate.

D. Others:

    略.

E. Reference：

     Robbins Pathologic Basis of Disease, 6^th ed.  P.1012-1013.

　

 

 

【 Fig. 75-1 (1X)】A branching , villous or papillary connective tissue stroma covered by a thickened hyperplastic epithelium.

　

 

 

【 Fig. 75-2 (2X)】A branching , villous or papillary connective tissue stroma covered by a thickened hyperplastic epithelium.

 

 

【 Fig. 75-3 (4X)】Distinct perinuclear clear vacuolization of the prickle cells (koilocytosis) as characteristic of HPV infection..

　

 

 

【 Fig. 75-4 (10X)】The epithelium shows considerable superficial hyperkeratosis, parakeratosis and thickening of the underlying epidermis (acanthosis) with thickening and elongation of the rete ridges.

　

 

 

【 Fig. 75-5 (20X)】Koilocytic atypia seen in this view.

　

 

 

【 Fig. 75-6 (40X)】Koilocytic atypia seen in this view.