《Slide 105.》Burkitt lymphoma, Appendix
A. Brief Descriptions：
Burkitt lymphoma is a highly aggressive lymphoma often presenting at extranodal sites or as an acute leukemia.
Three clinical variants: (1) Endemic (African) Burkitt lymphoma: EBV. (2) Sporadic (nonendemic) Burkitt lymphoma. (3) Immunodeficiency associated Burkitt lymphoma.
B. Gross Findings：
Involved organs are replaced by masses of fish-appearing tissue.
C. Micro Findings：
Diffuse monotonous infiltration with a “starry sky” pattern.
Intermediate-sized lymphoid cells: round or oval nuclei with coarse chromatin, several nucleoli, and a moderate amount of basophilic cytoplasm.
Mitotic figures are numerous.
Numerous benign macrophages that have ingested apoptotic tumor cell→“stars”.
Robbins Pathologic Basis of Disease, 6th ed. P.662-663.
【 Fig. 105-1 (LP)】Diffusely lymphoid infiltrates through the whole layers of the appendix.
【 Fig. 105-2 (LP)】Starry sky.
【 Fig. 105-3 (HP)】Diffuse infiltration of monotonous lymphoid cells of intermediate size have round or oval nuclei with coarse chromatin, distinct nucleoli.Mitotic figures are easily found.
【 Fig. 105-4 (HP)】Numerous benign macrophages that have ingested apoptotic tumor cell makes the presence of "star".