《Slide 105.》Burkitt lymphoma, Appendix

A. Brief Descriptions：

  1. Burkitt lymphoma is a highly aggressive lymphoma often presenting at extranodal sites or as an acute leukemia.

  2. Three clinical variants: (1) Endemic (African) Burkitt lymphoma: EBV. (2) Sporadic (nonendemic) Burkitt lymphoma. (3) Immunodeficiency associated Burkitt lymphoma.

B. Gross Findings：

  1. Involved organs are replaced by masses of fish-appearing tissue.

     

C. Micro Findings：

  1. Diffuse monotonous infiltration with a “starry sky” pattern.

  2. Intermediate-sized lymphoid cells: round or oval nuclei with coarse chromatin, several nucleoli, and a moderate amount of basophilic cytoplasm.

  3. Mitotic figures are numerous.

  4. Numerous benign macrophages that have ingested apoptotic tumor cell→“stars”.

D. Others:

    略.

E. Reference：

  1. Robbins Pathologic Basis of Disease, 6th ed.  P.662-663.

　

 

 

【 Fig. 105-1 (LP)】Diffusely lymphoid infiltrates through the whole layers of the appendix.

　

 

【 Fig. 105-2 (LP)】Starry sky.

　

 

 

【 Fig. 105-3 (HP)】Diffuse infiltration of monotonous lymphoid cells of intermediate size have round or oval nuclei with coarse chromatin, distinct nucleoli.Mitotic figures are easily found.

　

　

【 Fig. 105-4 (HP)】Numerous benign macrophages that have ingested apoptotic tumor cell makes the presence of "star".