Slide 184.Nodular goiter, Thyroid

A. Brief Descriptions

  1. Recurrent episodes of hyperplasia and involution combine to produce irregular enlargemen of the thyroid.

  2. Hyperplasia of the thyroid gland may result from hyperstimulation by: (1)TSH, (2)Ab to TSH receptor, (3)iodine deficiency, (4)goitrogens in food, or (5)drugs.

  3. Nontoxic, thyrotoxicosis.

  4. Sporadic and endemic forms, female/male:1/1.

B. Gross Findings

  1. Multilobulated, asymmetrically enlarged glands.

  2. Cut section: irregular nodules with variable amounts of brown and gelatinous colloid.

C. Micro Findings

  1. Colloid rich follicles lined by flatten, inactive epithelium and areas of follicular epithelial hypertrophy and hyperplasia.

  2. Degenerative changes: hemorrhage, fibrosis, calcification, and cystic.

D. Others:


E. Reference

  1. Robbins Pathologic Basis of Disease, 6th ed.  P.1139.




Fig. 184-1 (4X)




Fig. 184-2 (4X)




Fig. 184-3 (10X)




Fig. 184-4 (10X)




Fig. 184-5 (10X)




Fig. 184-6 (20X)




Fig. 184-7 (20X)




Fig. 184-8 (20X)




Fig. 184-9 (20X)