《Slide 94.》Pheochromocytoma, Adrenal gland

A. Brief Descriptions：

1. Uncommon neoplasm composed of chromaffin cells: synthesize and release catecholamine.

2. Paraganglioma of adrenal medulla.

3. 10% tumor: 10% malignant, 10% bilateral, 10% extra-adrenal .

B. Gross Findings：

1. Small, circumscribed lesions confined to the adrenal to large hemorrhagic masses weighing kilogram.

2. Incubation of fresh tissue with potassium dichromate solution: dark brown color.

C. Micro Findings：

1. Arranged in well-defined nests (zellballen) bounded by delicate fibrovascular stroma, which may contain amyloid.

2. Cells vary in size & shape & have a finely granular & basophilic or eosinophilic or lipid-containing cytoplasm.

3. Round or oval vesicular nuclei with prominent nucleoli & sometimes. inclusion-like structure due to deep cytoplasmic invagination.

4. Nuclear gigantism & hyperchromasia are not an expression of malignancy.

D. Others:

   略.

E. Reference：

1. Robbins Pathologic Basis of Disease, 6^th ed.  P.1165.

　

 

 

【 Fig. 94-1 (1X)】

　

 

 

 

【 Fig. 94-2 (2X)】

　

 

 

【 Fig. 94-3 (4X)】

　

 

 

【 Fig. 94-4 (4X)】

　

 

 

【 Fig. 94-5 (4X)】

　

 

 

【 Fig. 94-6 (10X)】

　

 

 

【 Fig. 94-7 (10X)】

　

 

 

【 Fig. 94-8 (20X)】

　

 

 

【 Fig. 94-9 (40X)】

　

 

 

【 Fig. 94-10 (40X)】