Slide 94.Pheochromocytoma, Adrenal gland

A. Brief Descriptions

  1. Uncommon neoplasm composed of chromaffin cells: synthesize and release catecholamine.

  2. Paraganglioma of adrenal medulla.

  3. 10% tumor: 10% malignant, 10% bilateral, 10% extra-adrenal .

B. Gross Findings

  1. Small, circumscribed lesions confined to the adrenal to large hemorrhagic masses weighing kilogram.

  2. Incubation of fresh tissue with potassium dichromate solution: dark brown color.

C. Micro Findings

  1. Arranged in well-defined nests (zellballen) bounded by delicate fibrovascular stroma, which may contain amyloid.

  2. Cells vary in size & shape & have a finely granular & basophilic or eosinophilic or lipid-containing cytoplasm.

  3. Round or oval vesicular nuclei with prominent nucleoli & sometimes. inclusion-like structure due to deep cytoplasmic invagination.

  4. Nuclear gigantism & hyperchromasia are not an expression of malignancy.

D. Others:


E. Reference

  1. Robbins Pathologic Basis of Disease, 6th ed.  P.1165.




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