Slide 89.Subacute thyroiditis, Thyroid

A. Brief Descriptions

  1. Granulomatous thyroiditis or DeQuervain thyroiditis.

  2. Frequent in women between the ages of 30 and 50.

  3. Caused by a viral infection or a postviral inflammatory process.

  4. Sudden onset of painful enlargement of thyroid with 3 phases of course. (hyperthyroid, hypothryoid & recovery).

B. Gross Findings

  1. Asymmetrical or uneven involvement of the gland.

  2. Firm & irregular white-tan lesion or several small poorly demarcated nodules (from several mm to a few cm) on cut surface.

C. Micro Findings

  1. Vary with the phase.

  2. Initially, desquamation or degeneration of follicular epithelium with colloid depletion, then acute inflammatory response with PMNs & microabscesses.

  3. Then follicular epithelium disappear & replaced by a rim of histiocytes & giant cells (foreign body giant cells form around remnants of colloid after follicle degenerate completely).

  4. Interstitial fibrosis & infiltration of lymphocytes, plasma cells, & histiocytes.

D. Others:


E. References

  1. Robbins Pathologic Basis of Disease, 6th ed.  P.1135.




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