Slide 90.Hashimoto’s thyroiditis, Thyroid

A. Brief Descriptions

  1. This disorder is most prevalent between 45 and 65 years of ge and is more common in women than in man, with a female predominance of 10:1 to 20:1.

  2. Autoimmune thyroiditis & struma lymphomatosa.

  3. Symptoms and signs: euthyroidism or hypothyroidism.

B. Gross Findings

  1. Symmetric enlargement with tan yellow cut surface.

  2. Intact capsule.

C. Micro Findings

  1. Oxyphilic change of follicular epithelium: small & atrophic thyroid follicles with oxyphilic metaplasia of follicular cells ranging from pale pink staining cells with abundant cytoplasm to oxyphilic cells with pink granular cytoplasm.

  2. Lymphoplasmcytic infiltration with prominent germinal centers in the stroma.

  3. Scanty connective tissue with slightly thickening of inter-lobular septi.

D. Others:


E. Reference

  1. Robbins Pathologic Basis of Disease, 6th ed.  P.1134.




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