《Slide 126.》Nodular glomerulosclerosis, Kidney

A. Brief Descriptions：

1. DM related nephropathy.

B. Gross Findings：

  略.

C. Micro Findings：

1. Tubules: Armanni-Ebstein change ( glycogen deposits within tubular epithelial cells).

2. Variable change of interstitium depending on infection or not.

3. Glomeruli:

   • Acellular, homogeneous, eosinophilic, globular nodules in the mesangial orintercapillary region of a glomerular tuft with capillary displaced to the periphery.

   • Diffuse intercapillary glomerulosclerosis: increasing eosinophilic mesangial matrix materials.

   • Capsular drop: eosinophilic small nodules on Bowman's capsule.

   • Fibrin cap: eosinophilic, waxy, fatty structure within the lumen of one or more capillary loops of glomerular tufts.

D. Others:

1. Diabetic nephropathy:

• Severe arteriolar nephrosclerosis.

• Nodular glomerulosclerosis.

• Some acute or chronic pyelonephritis.

E. Reference：

1. Robbins Pathologic Basis of Disease, 6^th ed.  p.967

　

 

 

【 Fig. 126-1 (10X)】Nodular sclerosis of glomeruli are the characteristic.

　

 

 

【 Fig. 126-2 (40X)】Nodular sclerosis of glomeruli are seen in this high power field.

　

 

 

【 Fig. 126-3 (4X)】Charateristic nodular sclerosing pattern.

　

 

 

【 Fig. 126-4 (10X)】Some global sclerosis of glomeruli are seen, too.