《Slide 127.》Chronic glomerulonephritis, Kidney

A. Brief Descriptions：

1. Chronic glomerulonephritis is best considered an end-stage pool of glomerular disease fed by a number of streams of specific types of glomerulonephritis

2. Poststreptococcal GN, rapidly progressive GN, membranous GN, focal glomerulosclerosis, membranoproliferative GN, …etc. à chronic GN.

B. Gross Findings：

1. Small, firm kidney with granular subcapsular surface & narrowed cortex.

C. Micro Findings：

1. Changes varying greatly, the following may be found:

• Glomeruli:

  • Reduced number

  • Small, solid tuft, some with cellular proliferation & adhesion of tuft & capsule, or crescent formation.

• Tubules:

         Loss, atrophy, or dilatation, some with infection.

D. Others:

   略.

E. Reference:

1. Robbins Pathologic Basis of Disease, 6^th ed.  p.963-964

　

 

 

【 Fig. 127-1 (4X)】Small, solid tuft, some with cellular proliferation and adhesion of tuft and capsule.

　

 

 

【 Fig. 127-2 (10X)】Glomerulus undergoes sclerosis.

　

 

 

【 Fig. 127-3 (4X)】Glomerulosclerosis seen in left lower field and tubular atrophy with chronic inflammatory infiltrate.

　

 

【 Fig. 127-4 (4X)】Atrophic renal tubules with chronic inflammatory infiltrate and hemorrhage in fibrous stroma.