¡mSlide 132.¡nRenal cell carcinoma, Kidney
A. Brief Descriptions¡G
Tumors arise from tubular epithelial cells; Tobacco is the most prominent risk factor; often in older; preponderance in men.
Classic symptoms: hematuria, loin pain & mass.
Classification of RCC: clear cell (nonpapillary) carcinoma (70% to 80%) ; papillary carcinoma(10% to 15%); chromophobe renal carcinoma (5%).
B. Gross Findings¡G
Protruding from renal cortex, as an irregular, bosselated mass, expansile growth with compressing adjacent renal parenchyma into a pseudocapsule. Cut surface often hemorrhagic, grayish white to yellow, and cystic change or necrosis.
C. Micro Findings¡G
Clear cytoplasm due to high contain of lipid & glycogen.
Prominent cell borders and tightly adherent to neighboring cells.
Granular cell: pink granular cytoplasm due to high content of mitochondria.
Arrange in sheets, nests, cords, tubular or papillary pattern with a fine capillary vascular background, and separated by fibrous septi.
Little cellular or nuclear pleomorphism or mitosis.
Necrosis, fibrosis, cholesterol deposit ( may with foreign body reaction), hemorrhage, calcification or cystic change.
Peak at sixth decade, male 2-3 times more frequently than female ; higher incidence in Jews.
Robbins Pathologic Basis of Disease, 6th ed. p.991-994
¡i Fig. 132-1 (2X)¡jTumor mass is seen left field and normal architecture is seen in right view in this scanning field.
¡i Fig. 132-2 (4X)¡jTumor exhibits clear appearnce.
¡i Fig. 132-3 (10X)¡jClear cytoplasm due to high contain of lipid & glycogen.
¡i Fig. 132-4 (40X)¡jClear cytoplasm due to high contain of lipid & glycogen..