《Slide 133.》Squamous cell carcinoma, Kidney

A. Brief Descriptions：

1. Infiltration of tumor cells with a spiky or angular outline which are surrounding by a fibroblastic or fibrous stroma.

2. Related to renal stone.

B. Gross Findings：

  略.

C. Micro Findings：

1. Infiltration of tumor cells with a spiky or angular outline which are surrounding by a fibroblastic or fibrous stroma

2. Renal tumor with extensive keratinization (layered eosinophilic materials);note normal renal parenchyma and squamous metaplasia of renal pelvic transitional epithelium

3. Keratinized squamous cancer cells with infiltrating borders; note dilated atrophic ducts

D. Others:

1. Differentiated diagnosis from squamous metaplasia of urothelium (lack of dysplasia) and  transitional cell carcinoma with squamous metaplasia.

E. Reference：

1. Robbins Pathologic Basis of Disease, 6^th ed.  p.262 and p.1006-1007

　

 

【 Fig. 133-1 (2X)】Keratinized squamous cancer cells with infiltrating borders in this scanning view.

　

 

【 Fig. 133-2 (10X)】Tumor cells demonstrating keratinization.

　

　

 

【 Fig. 133-3 (20X)】The tumor cells show pleomorphism and hyperchromatism.
  Keratinization is seen in left view.

　

 

【 Fig. 133-4 (40X)】The tumor cells show pleomorphism and hyperchromatism.
 Mitoses is seen in this view.