Slide 134.Wilms' tumor, Kidney

A. Brief Descriptions

  1. Wilms’ tumor is also known as nephroblastoma, embryoma, carcinosarcoma, adenosarcoma, and adenomyosarcoma.

  2. It is seen primarily in infants, 50% of the cases occurring before the age of 3 years and 90% before the age of 6 years.

B. Gross Findings

  1. Large,solitary,well-circumscribed mass

  2. Tan to gray、soft 、homogeneous on cut surface

C. Micro Findings

  1. Classic triphasic components:

D. Others:

  1. 10% are bilateral or multiple.

E. Reference

  1. Robbins Pathologic Basis of Disease, 6th ed.  p.487-489




Fig. 134-1 (2X)Relatively solitary well-circumscribed mass.The most are Blastemal type.



Fig. 134-2 (10X)】Most are oval to round hyperchromatic cancer cells with  scanty cytoplasm.The lesion is Blastemal type.



【 Fig. 134-3 (10X)】Some area shows more spindle cells type with eosinophilic stroma indicating stromal differentiation.



【 Fig. 134-4 (10X)】Focal glandular formation is seen in this view indicating toward epithelial differention.