Slide 122.Islet Cell Tumor, Pancreas

A. Brief Descriptions

  1. Endocrine pancreatic tumor.

  2. Rare in comparison with the exocrine pancreatic tumors.

  3. Insulinomas are the most common of islet cell tumors.

  4. Resemble carcinoid tumor found in elsewhere in the alimentary tract.

B. Gross Findings


C. Micro Findings

  1. Arranged in anastomosing cords separated by a vascular stroma.

  2. Solid clumps of cells with a sparse, collagenous stroma between the clumps.

  3. Small acini and central necrosis may be presented in the clumps.

  4. The cells at the margin of the clumps sometimes forms a palisade.

D. Others:

  1. Tumor often encapsulated.

  2. Insulinoma & Gastrinoma are classified according to the cell type that is predominant in the tumor.

E. Reference

  1. Robbins Pathologic Basis of Disease, 6th ed.  P.926-927.




Fig. 122-1 (LP)Rather well-defined, encapsulated nodule arising from pancreas. Note the normal pancreas in the left.



Fig. 122-2 (LP)The normal pancreatic parenchyma is composed of exocrine pancreatic acini/ducts (eosinophilic area) and endocrine islands of Langerhans (paler nodules).



Fig. 122-3 (LP)The tumor is composed of uniform cells arranged in anastomosing cords.



Fig. 122-4 (HP)The tumor is vascular-riched with abundant vasculature.