《Slide 60.》Granular cell tumor, Tongue

A. Brief Descriptions：

1. Formerly known as granular cell myeloblastoma or granular cell schwannoma.

2. Benign lesion of probable Schwann cell origin.

3. Young or middle aged adult, female predominant.

B. Gross Findings：　

1. Solitary dermal or subcutaneous nodules.

C. Micro Findings：

1. Ill-defined mass composed of a diffuse sheet of large, pale eosinophilic polygonal cells with granular cytoplasm and a small, central nucleus.

2. Hyperkeratosis of overlying mucosa.

D. Others:

    略.

E. Reference:

  略.

 

 

【 Fig. 60-1 (LP)】Tumor nodules interrupt the muscle bundles of tongue. The overlying mucosa shows hyperkeratosis.

 

 

【 Fig. 60-2 (LP)】The tumor compose of sheets of large, pale, eosinophilic polygonal cells.

　

 

【 Fig. 60-3 (LP)】The tumor compose of sheets of large, pale, eosinophilic polygonal cells.

　

 

【 Fig. 60-4 (HP)】The large tumor cell have granular cytoplasm and central located, round nucleus.