《Slide 68B.》Adenocarcinoma, M-D, Colon

A. Brief Descriptions：

1. Malignant epithelial tumor of colon.

2. Most colorectal carcinoma are located in sigmoid colon and rectum.

3. The percentage of the tumor showing formation of gland-like structure can be used to be defined the grade:

•  well-differentiated: > 95% gland-like structure.

• moderate-differentiated: 50 to 95% gland-like structure.

• poor-differentiated: 5 to 50 % gland-like structure.

• undifferentiated: < 5% gland-like structure.

B. Gross Findings：

1. Polypoid, exophytic or ulcerated tumor masses. 

C. Micro Findings：

1. Gland-forming with variability in size and configuration.

2. Large, stratified, hyperchromatic cells with high nuclear/ cytoplasm ratio and mitotic counts.

D. Others:

    略.

E. Reference：

1. Robbins Pathologic Basis of Disease, 6^th ed.  P.833 ~ 835.

 

 

【 Fig. 68B-1 (LP)】The tumor arise from epithelial mucosa and extending to the peripheral fatty tissue.

　

 

【 Fig. 68B-2 (LP)】The neoplastic gland with variability in size and configuration.

　

 

 

【 Fig. 68B-3 (LP)】Some neoplastic glands forms cribriform-pattern.

　

 

 

【 Fig. 68B-4 (LP)】Focal necrosis is noticed.

　

 

 

【 Fig. 68B-5 (HP)】The tumor cells have pleomorphic, vesicular nuclei with some distinct nucleoli.Mitotic figures are noticed.