《Slide 68B.》Adenocarcinoma, M-D, Colon
A. Brief Descriptions：
Malignant epithelial tumor of colon.
Most colorectal carcinoma are located in sigmoid colon and rectum.
The percentage of the tumor showing formation of gland-like structure can be used to be defined the grade:
well-differentiated: > 95% gland-like structure.
moderate-differentiated: 50 to 95% gland-like structure.
poor-differentiated: 5 to 50 % gland-like structure.
undifferentiated: < 5% gland-like structure.
B. Gross Findings：
Polypoid, exophytic or ulcerated tumor masses.
C. Micro Findings：
Gland-forming with variability in size and configuration.
Large, stratified, hyperchromatic cells with high nuclear/ cytoplasm ratio and mitotic counts.
Robbins Pathologic Basis of Disease, 6th ed. P.833 ~ 835.
【 Fig. 68B-1 (LP)】The tumor arise from epithelial mucosa and extending to the peripheral fatty tissue.
【 Fig. 68B-2 (LP)】The neoplastic gland with variability in size and configuration.
【 Fig. 68B-3 (LP)】Some neoplastic glands forms cribriform-pattern.
【 Fig. 68B-4 (LP)】Focal necrosis is noticed.
【 Fig. 68B-5 (HP)】The tumor cells have pleomorphic, vesicular nuclei with some distinct nucleoli.Mitotic figures are noticed.