《Slide 159.》Japanese B encephalitis, Cerebrum

A. Brief Descriptions：

1. Arbovirus, animal host and mosquito vectors.

B. Gross Findings：

1. Acute cases: only congestion and swelling of the brain.

2. Chronic cases: areas of cerebral softening and deposition of mineral within brain.

C. Micro Findings：

1.   Perivascular cuffing and parenchymal inflammatory infiltrates.

2.   Inflammatory nodules.

D. Others:

1. Meningoencephalitis: 是parenchyma的感染，不過常伴隨有腦膜的發炎。

2. Mosquito vectors: Culex pipiens、Culex tritaeniorhynchus、other Culex spp.、Aedes vexans、Anopheles spp.

3. Reservoir animals: snake、swan、horses、birds.

4. Incubation peroid: 6~16 days.

5. Mortality: 50% in infants and child。7%~ 33% in adults.

6. Morbidity: persistent neurologic disability in survivors.

E. Reference：

1. Robbins Pathologic Basis of Disease, 6^th ed.  P.1318.

 

 

【 Fig. 159-1 (LP)】Edematous cerebrum with gliosis, note inflammatory nodule and perivascular lymphoid cuffing.

　

 

 

【 Fig. 159-2 (LP)】Perivascular lymphoid cuffing.