《Slide 97.》Malignant melanoma, Eye
A. Brief Descriptions：
Arising from pigmented neuroepithelia or uveal melanocytes.
Most common in posterior choroid in eye.
B. Gross Findings：
Apple & Blodi classification
Obvious and unquestionable nevi and melanocytoma
Phase A tumor:
Relatively small, not extended or metastatic beyond eye
Most cells classified toward benign end and stationary or slow growing
Phase B tumor:
Large, extensive and rapid growth with malignant bizarre cells
Spindle A and spindle B cell groups
Slender, elongated, spindle shape, cohesive cells
With poorly visualized cell border
Slender, elongated, spindle shaped nuclei
Spindle A cells : devoid of nucleolus
Spindle B cells : larger, with prominent nucleoli
Fascicular: cells in parallel rows, bundles about dilated vessels, with palisading nuclei
Mixed spindle and epithelioid cells
Larger cells variation in size and shape
Well-demarcated, poorly cohesive
Abundant cytoplasm, hyperchromatic nucleus with prominent nucleoli
Multinucleated tumor giant cells
C. Micro Findings：
Tumor grows into vitrous cavity with elevated retinal layer with dark-brown melanin pigments.
Epithelioid cells with large cell size, abundant cytoplasm, hyperchromatic nuclei and prominent nucleoli.
Layer of spindle cells, some with prominent nucleoli.
Arising from pigmented neuroepithelia or uveal melanocyte
Most common in posterior choroid in eye
Robbins pathologic basis of disease. Ch31. p.1366-1367.
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