Slide 208.Rheumatoid nodules, Joint

A. Brief Descriptions

  1. Rheumatoid nodule within the substance of the synovial membrane in a patient with rheumatoid arthritis.

  2. Rheumatoid nodules are present in approximately 20% to 25% of patients with rheumatoid arthritis.

B. Gross Findings

  1. Solitary or multiple, nontender, firm, freely movabile, large subcutaneous nodules.

C. Micro Findings

  1. Center: homogenous eosinophilic fibrinoid degeneration of collagen.

  2. Periphery: peripheral palisade of histiocytes and lymphocytes.

D. Others:


E. Reference

  1. Robbins Pathologic Basis of Disease, 6th ed.  P1248-1251.




Fig. 208-1 (LP)





Fig. 208-2 (LP)A typical serpiginous zone (top) of amorphous, eosinophilic, fibrinoid material surrounded by palisading histiocytes and lymphocytes.