《Slide 208.》Rheumatoid nodules, Joint
　

A. Brief Descriptions：

1. Rheumatoid nodule within the substance of the synovial membrane in a patient with rheumatoid arthritis.

2. Rheumatoid nodules are present in approximately 20% to 25% of patients with rheumatoid arthritis.

B. Gross Findings：

1. Solitary or multiple, nontender, firm, freely movabile, large subcutaneous nodules.

C. Micro Findings：

1. Center: homogenous eosinophilic fibrinoid degeneration of collagen.

2. Periphery: peripheral palisade of histiocytes and lymphocytes.

D. Others:

      略.

E. Reference：

1. Robbins Pathologic Basis of Disease, 6^th ed.  P1248-1251.

　

 

 

【 Fig. 208-1 (LP)】

　

　

　

 

【 Fig. 208-2 (LP)】A typical serpiginous zone (top) of amorphous, eosinophilic, fibrinoid material surrounded by palisading histiocytes and lymphocytes.