《Slide 10.》Hemosiderin (hemochromatosis), Liver
A. Brief Descriptions:
Hemochromatosis : the excessive accumulation of body iron (most in liver and pancreas).
Cause: (1)genetic or (2)secondary.
B. Gross Findings:
Enlarged(slight), brown to chocolate brown, firm liver(cirrhosis).
C. Micro Findings:
Early: normal liver architecture, brown or golden yellow hemosiderin in peri-portal hepatocytes.(zone 1).
Later: more general distribution of hemosiderin in hepatocytes & Kupffer cells, most in peri-portal zone, increasing fibrosis & lymphocytic infiltration along portal areas, then diffuse irregular fibrosis, cirrhosis.
D. Others:
病理組織重點:Brown or golden yellow hemosiderin in hepatocytes.
E. Reference:
Robbins Pathologic Basis of Disease, 6th ed. P.873-875.
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【 Fig. 10-1 (LP)】
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【 Fig. 10-2 (LP)】
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【 Fig. 10-3 (HP)】