Slide 9.Melanin (Malignant melanoma), Eye

A. Brief Descriptions

  1. Intraocular melanoma is common in Caucasians.

  2. It occurs on the uveal tract (the iris; ciliary body; and choroids) , on the skin of lid , on the conjunctiva and with in the orbit.

B. Gross Findings

  1. Striking variations in pigmentation--black、brown、red、dark blue、gray.

C. Micro Findings

 It is hard to identify the cell shape or type without remove the melanin.

D. Others:

Origin of melanoma of the eye.

  1. Melanocytes of the uvea (iris、ciliary body、choroid).

  2. Pigmented epithelium of the retina.

  3. Mostly from posterior choroid.

E. Reference

  1. Robbins Pathologic Basis of Disease, 6th ed.  P.1365-1367.



Fig. 9-1 (LP)




Fig. 9-2 (LP)




Fig. 9-3 (HP)




Fig. 9-4 (HP)




Fig. 9-5 (HP)