《Slide 24.》Cardiac congestion, Liver
A. Brief Descriptions：
Chronic passive congestion of the liver ; so-called nutmeg liver.
Cause: Right –side heart failure , chronic passive congestion of the liver.
B. Gross Findings：
Dark congested & hemorrhagic perivenular areas with paler zone 2 areas (yellowish tinge due to fatty change) & pale periportal areas.
C. Micro Findings：
Congestive changes and accentuation of the centrilobular areas surrounded by paler hypoxic regions.
In severe form: central lobular necrosis appear along with sinusoidal congestion with persistence, it become sclerotic → cardiac cirrhosis.
Robbins Pathologic Basis of Disease, 6th ed. P.116-117.
【 Fig. 24-1 (LP)】Destruction of regular liver structure especially in the central areas (perivenular areas).
【 Fig. 24-2 (LP)】Sinusoidal congestion and necrosis of hepatocytes in the perivenular areas; note the portal area (right low) is not affected.
【 Fig. 24-3 (LP)】Necrosis of perivenular hepatocytes.
【 Fig. 24- (HP)】Necrosis of perivenular hepatocytes.