《Slide 24.》Cardiac congestion, Liver

A. Brief Descriptions：

1. Chronic passive congestion of the liver ; so-called nutmeg liver.

2. Cause: Right –side heart failure , chronic passive congestion of the liver.

B. Gross Findings：

1. Dark congested & hemorrhagic perivenular areas with paler zone 2 areas (yellowish tinge due to fatty change) & pale periportal areas.

C. Micro Findings：

1. Congestive changes and accentuation of the centrilobular areas surrounded by paler hypoxic regions.

2. In severe form: central lobular necrosis appear along with sinusoidal congestion with persistence, it become sclerotic → cardiac cirrhosis.

D. Others:

   略.

E. Reference：

1. Robbins Pathologic Basis of Disease, 6^th ed.  P.116-117.

　

 

 

【 Fig. 24-1 (LP)】Destruction of regular liver structure especially in the central areas (perivenular areas).

　

 

【 Fig. 24-2 (LP)】Sinusoidal congestion and necrosis of hepatocytes in the perivenular areas; note the portal area (right low) is not affected.

　

 

【 Fig. 24-3 (LP)】Necrosis of perivenular hepatocytes.

　

  

【 Fig. 24- (HP)】Necrosis of perivenular hepatocytes.