Slide 42.Actinomycosis, Tongue

A. Brief Descriptions

  1. A chronic suppurative disease caused by anaerobic, filamentous Actinomycetales.

B. Gross Findings

  1. Lesions with abscess or draining sinus tracts with "sulfur granules".

C. Micro Findings

  1. Suppurative inflammation with abscess formation that contain one or more granules (organized aggregates of filaments), 30 to 3000 um in diameter, that are bordered by eosinophilic, club-like (Sendore-Hoeppli materials) filaments.

  2. Bacterial stain reveal that the granules are composed of delicate, branched, Gram-positive filaments, 1 um diameter, haphazardly arranged in an amorphous matrix.

D. Others:


E. Reference

  1. Robbins Pathologic Basis of Disease, 6th ed.  P.332-335.



Fig. 42-1 (LP)Abscess within intrinsic muscle of tongue (central basophilic area).



Fig. 42-2 (LP)A large, pink-purple granule within abscess area. Note residual intrinsic muscle of tongue at the left.



Fig. 42-3 (LP)The pink-purple granule (sulfur granule) is surrounded by lymphocytes at periphery.




Fig. 42-4 (HP)The sulfur granule is composed of filamentous Actinomycetales with radial arrangement at periphery and surrounded by a rim of lymphocytes.