Slide 43.Cytomegalovirus (CMV) infection, Kidney

A. Brief Descriptions

  1. In healthy individuals ---- asymptomatic or mononucleosis-like infection.

  2. Immunosuppressed patients or neonates ---- devastating systemic infection.

  3. Patients with AIDS ---- almost always accompanied by Pneumocystis carinii.

  4. Recipients of autologous marrow transplants ---- interstitial pneumonitis.

B. Gross Findings


C. Micro Findings

  1. Intracytoplasmic or intranuclear inclusion in tubule.

  2. Basophilic inclusion surrounded by a clear halo -- bull eye appearance.

  3. Interstitial inflammation may present.

D. Others:

  1. Opportunistic infection.

  2. Salivary gland, kidney, liver, lung, pancreas, thyroid, adrenal gland, brain are frequently affected.

E. Reference

  1. Robbins Pathologic Basis of Disease, 6th ed.  P.376.




Fig. 43-1 (LP)There are foci of concentrated inflammatory infiltrate in renal parenchyma.



Fig. 43-2 (LP)Enlarged CMV-infected renal tubular epithelial cells withprominent intranuclear inclusion surrounded by a clear halo (bull-eye appearance).



Fig. 43-3 (HP)CMV-infected renal tubular epithelial cell with typical bull-eye appearance. Note the rather enlarged CMV-infected cell as compared to adjacent normal renal tubular epithelial cells.