《Slide 43.》Cytomegalovirus (CMV) infection, Kidney
A. Brief Descriptions：
In healthy individuals ---- asymptomatic or mononucleosis-like infection.
Immunosuppressed patients or neonates ---- devastating systemic infection.
Patients with AIDS ---- almost always accompanied by Pneumocystis carinii.
Recipients of autologous marrow transplants ---- interstitial pneumonitis.
B. Gross Findings：
C. Micro Findings：
Intracytoplasmic or intranuclear inclusion in tubule.
Basophilic inclusion surrounded by a clear halo -- bull eye appearance.
Interstitial inflammation may present.
Salivary gland, kidney, liver, lung, pancreas, thyroid, adrenal gland, brain are frequently affected.
Robbins Pathologic Basis of Disease, 6th ed. P.376.
【 Fig. 43-1 (LP)】There are foci of concentrated inflammatory infiltrate in renal parenchyma.
【 Fig. 43-2 (LP)】Enlarged CMV-infected renal tubular epithelial cells withprominent intranuclear inclusion surrounded by a clear halo (bull-eye appearance).
【 Fig. 43-3 (HP)】CMV-infected renal tubular epithelial cell with typical bull-eye appearance. Note the rather enlarged CMV-infected cell as compared to adjacent normal renal tubular epithelial cells.