Slide 45.Candidasis, Brain

A. Brief Descriptions

  1. The most common cause of human fungal infection.

  2. Grow as yeast forms, tandem arrays of elongated forms without hyphae (psudohyphae).

  3. Warm, moist surface; chronic mucocutaneous candidiasis; severe disseminated candidiasis.

B. Gross Findings


C. Micro Findings

  1. Abscess formation surrounded by a rim of gliosis.

  2. Candida are seen among acute and chronic inflammatory cells near the abscess wall.

D. Others:

  1. 90% caused by Candida albicans.

  2. Ovoid yeast 3-4 m m, non - branching pseudohyphae and yeast joint end to end.

  3. Developed when body defense mechanism is lowered; e.g. in immunodeficiency, immunosuppressant.

  4. Candidemia is rare ; if disseminate , it would cause brain abscess, with local sign & can cause shock.

E. Reference:

  1. Robbins Pathologic Basis of Disease, 6th ed.  P.378-379.



Fig. 45-1 (LP) Several nodular structures within brain parenchyma.




Fig. 45-2 (LP)The nodular strictures are composed of necrotic debris and inflammatory cells.




Fig. 45-3 (HP)There are many yeast-form and filamentous-form fungal organisms within necrotic area.



Fig. 45-4 (HP)The sprouting yeast-form fungi aligned in single array side-by-side resembling filemantous structure with hyphae (pseudohyphae).