Slide 31.Signet ring cell carcinoma, Stomach

A. Brief Descriptions

     The World Health Organization classification subdivides gastric carcinoma into five subtype : papillary , 

     tubular , mucinous , and signet-ring cell adenocarcinomas and undifferentiated carcinoma.

B. Gross Findings

     Thickened & rigid of gastric walls, with or without mucosal ulceration.

C. Micro Findings

  1. Intracytoplasmic mucin resulting in the typical signet ring appearance.

  2. Infiltration of cancer cells through whole layers with occasional glandular formation & mucin pooling.

  3. Extensive fibrosis (desmoplasia) & dense inflammatory infiltration.

D. Others:

      Linitis plastica (leather-bottle stomach).

E. Reference

     Robbins Pathologic Basis of Disease, 6th ed.  P.798-802.




Fig. 31-1 (1X)Nests of cancer cells seen in right field.




Fig. 31-2 (1X)Nests of cancer cells seen in left field.




Fig. 31-3 (4X)Hyperchromatic cancer cells floating in the mucin pools.




Fig. 31-4 (10X)Hyperchromatic cancer cells floating in the mucin pools.




Fig. 31-5 (10X)Tumor invaded into subserosal layer.





Fig. 31-6 (40X)Signet-ring-like cells with intracytoplasmic mucin pooling and pushing the nuclei to the periphery.