《Slide 32.》Adrenocortical adenoma, Adrenal gland

A. Brief Descriptions：

1. Benign .

2. Tumors removed from patients with Cushing syndrome usually weigh less than 50g and measure 3 to 4 cm in diameter.

3. In broad terms, the majority of adrenal cortical adenomas occur in adults with a slight predilection for females.

B. Gross Findings：

     Well-circumscribed nodular masses (Usually < 5 cm. In diameter and 5-50 gm. In weight).

C. Micro Findings：

1. Adenomas are composed of uniform large cells arranged in nests and trabeculae.

2. The cells have abundant lipid-filled cytoplasm and small uniform nuclei.

3. Nuclear enlargement and pleomorphism are common, but mitotic figures are rare.

D. Others:

  略.

E. Reference：

     Robbins Pathologic Basis of Disease, 6^th ed.  P.1153-1157.

　

 

 

【 Fig. 32-1 (2X)】Well-circumscribed nodular masses with adrenal gland compressed to the periphery.

　

 

 

【 Fig. 32-2 (2X)】Tumor nest seen in right upper and normal adrenal gland seen in left lower field.

　

 

 

【 Fig. 32-3 (1X)】Well-circumscribed nodular masses.

　

 

  

【 Fig. 32-4 (2X)】Adenomas are composed of uniform large cells arranged in nests and trabeculae.

　

 

 

【 Fig. 32-5 (4X)】Adenomas are composed of uniform large cells arranged in nests and trabeculae.

　

 

 

【 Fig. 32-6 (40X)】The cells have abundant lipid-filled cytoplasm and small uniform nuclei.