《Slide 33.》Leiomyoma , Uterine corpus

A. Brief Descriptions：

1. The most common tumors in women and are referred to in colloquial usage as fibroids

2. Estrogen responsive; they regress or even calcify after castration or menopause and may undergo rapid increase in size during pregnancy

3. Cause: unknown

B. Gross Findings：

1. Solitary or multiple

2. Circumscribed, firm, grayish-white

3. On cut section: whirled appearance

C. Micro Findings：

1. Uniform proliferation of spindle-shaped smooth muscle cells with bilateral blunt end (cigar-shaped) nuclei

2. Cytological atypia is sometimes present, particularly in areas of hyalinization

3. Degenerative change (not in our slide)

D. Others:

    略.

E. Reference:

     Robbins Pathologic Basis of Disease, 6^th ed.  P.1063-1064.

　

 

 

【 Fig. 33-1 (2X)】Well defined tumor in right field.

　

 

 

【 Fig. 33-2 (2X)】Well circumscribed tumor in upper field.

　

 

 

【 Fig. 33-3 (4X)】Tumor is composed of spindle-shaped cells in whorl pattern.