《Slide 71.》Seminoma (classic type), Testis

A. Brief Descriptions：

     The most common germ cell tumors.

B. Gross Findings：

     Enlarged testis with a well-defined homogenous pale pinkish/white to light yellow tumor may contain  

     shapely circumscribed zones of necrosis.

C. Micro Findings：

1. Uniform spheroidal cells with abundant clear cytoplasm, shapely outlined cell membrane, a large centrally located nucleus & clumped chromatin pattern.

2. Prominent nucleolus with amphophilic staining, apparent multiplicity, elongated shaped & irregular contours.

3. Mitosis is variable.

4. Tumor cells arranged in nests outlined by fibrous bands which are infiltrated by lymphocytes & plasma cells.

D. Others:

     The most common single type of primary testicular tumor, in two forms: classic type (93%) &

    spermatocytic variety.

E. Reference：

     Robbins Pathologic Basis of Disease, 6^th ed.  P.1019-1020.

　

 

 

【 Fig. 71-1 (1X)】Tumor cells seen in upper field.

　

 

 

【 Fig. 71-2 (2X)】Uniform spheroidal cells with abundant clear cytoplasm, shapely outlined cell membrane.

　

 

 

【 Fig. 71-3 (3X)】Uniform spheroidal cells with abundant clear cytoplasm, shapely outlined cell membrane.

　

 

 

【 Fig. 71-4 (10X)】Tumor cells arranged in nests outlined by fibrous bands which are infiltrated by lymphocytes & plasma cells.

　

 

　

　

 

 

【 Fig. 71-5 (20X)】Tumor cells outlined by fibrous bands which are infiltrated by lymphocytes & plasma cells.

　

 

 

【 Fig. 71-6 (20X)】Tumor cells  outlined by fibrous bands which are infiltrated by lymphocytes & plasma cells.

　

 

 

【 Fig. 71-7 (40X)】Uniform spheroidal cells with abundant clear cytoplasm.

　

 

 

【 Fig. 71-8 (40X)】Uniform spheroidal cells with abundant clear cytoplasm.