《Slide 73.》Adenocarcinoma, Prostate

A. Brief Descriptions：

1. Carcinoma of the prostate is the most common form of cancer among men in the US.

2. Tends to occur in peripheral parts of the gland but also may occur in the transition zone.

B. Gross Findings：

1. Gray or yellowish, poorly delineated, firm areas.

2. Carcinoma invades the seminal vesicles and may extend into other pelvic organs.

C. Micro Findings：

1. Irregular, closely packed glands with papillary, loosely cribriform or fused glandular tumor, raggedly infiltration.

2. Enlarged, irregular, hyperchromatic or vesicular nuclei with prominent nucleoli.

D. Others:

1. Grading base on the degree of glandular differentiation & the growth pattern of the tumor in relation to the stroma.

2. Compare with slide 12 nodular hyperplasia of prostate.

E. Reference：

     Robbins Pathologic Basis of Disease, 6^th ed.  P.1029-1033.

　

 

 

【 Fig. 73-1 (2X)】Irregular glands raggedly infiltrated in prostate tissue.

　

 

 

【 Fig. 73-2 (4X)】Hyperchromatic neoplastic glands seen in left field.

　

 

【 Fig. 73-3 (4X)】Neoplastic glands in cribriform patterns.

　

　

 

【 Fig. 73-4 (10X)】Neoplastic glands in cribriform patterns.

　

 

 

【 Fig. 73-5 (10X)】Monotonous cells grow in this view.

　

 

 

【 Fig. 73-6 (10X)】Monolayer-cell growth seen in this view.

　

　

　

 

【 Fig. 73-7 (40X)】Hyperchromatic nuclei with coarse chromatin.