Slide 173.Squamous cell carcinoma & adenomyosis,
Uterine Corpus

A. Brief Descriptions:

  1. 95% of squamous cell carcinoma (SCC): keratinizing (well-differentiated) or nonkeratinizing (moderately differentiated) patterns.

  2. <5% of SCC: poorly differentiated small cell wquamous or small cell undifferentiated carcinomas.

  3. The uterine corpus can be directly invaded by SCC of cervix.

B. Gross Findings:

  1. Cancer: fungating (exophytic), ulcerating or infiltrative patterns.

  2. Adenomyosis: irregular fibrotic areas.

C. Micro Findings:

  1. Tumor nests composed of large epidermoid cell infiltrate the myometrium.

  2. Adenomyosis with ectopic islands of endometrial tissue in the myometrium is also present.

D. Others:

  1. Compare with squamous cell carcinoma in situ (slide 83).

E. Reference:

  1. Robbins Pathologic Basis of Disease, 6th ed.  P.1051-1053.




Fig. 173-1 (LP)Infiltrating tumor nests in the myometrium.




Fig. 173-2 (LP)Anaplastic epidermoid cells arranged in nesty pattern.




Fig. 173-3 (LP)Tumor cells with vesicular nuclei, conspicuous nucleoli and increased mitotic figures.