Slide 185.Squamous cell carcinoma, Uterine cervix

A. Brief Descriptions:

  1. Definition: a malignant neoplasm composed of squamous cells. While generally derived from stratified squamous epithelium, it may occur in sites, such as the endocervix, where columnar epithelium is normally present.

B. Gross Findings:

  1. Exophytic pattern: the tumor grows out from the surface, often as a polypoid excrescence.

  2. Endophytic pattern: the tumor infiltrates into the surrounding structures, without much surface growth.

C. Micro Findings:

  1. In addition to the mucosa lesion, the tumor cells are arranged in cell nests infiltrating to deep stomal tissue.

  2. The tumor cells: pleomorphism,  increased N/C ratio, increased mitotic figures, atypical mitosis. The nuclei show hyperchromatism and contain prominent nucleoli.

  3. Vascular invasion is present.

  4. Inflammatory cell in the fibrous stroma.

D. Others:

  1. Compare with squamous cell carcinoma in situ (slide 83) and squamous cell carcinoma and adenomyosis (slide 173).

E. Reference:

  1. Robbins Pathologic Basis of Disease, 6th ed.  P.1051-1053.




Fig. 185-1 (LP)Invasive tumor nests in the stroma.




Fig. 185-2 (LP)Anaplastic tumor cells.