《Slide 83.》Squamous cell carcinoma in situ, Cervix

A. Brief Descriptions:

1. Human papilloma virus (HPV) is currently considered and important factor in cervical oncogenesis.

2. Koilocytic atypia: nuclear atypia and perinuclear vacuolization → viral “cytopathic” effect; in the upper and middle lining squamous epithelium.

3. Classification:

• Dysplasia: mild, moderate and severe.

• Cervical intraepithelial neoplasia (CIN): CIN I, II, III.

• Squamous intraepithelial lesion (SIL): low-grade and high-grade.

B. Gross Findings:

    No significant lesion.

C. Micro Findings:

1. Full-thickness dysplasia without any differentiation: atypical cells with hyperchromatism, altered polarity, and irregular nuclei in the entire thickness of squamous epithelium.

2. Basement membrane is intact. No stromal invasion.

D. Others:

1. Compare with slide 185.

E. Reference:

1. Robbins Pathologic Basis of Disease, 6^th ed.  P.1049-1051.

　

 

 

【 Fig. 83-1 (LP)】Full-thickness dysplasia of squamous epithelium.

　

 

 

【 Fig. 83-2 (LP)】Altered polarity of the epithelium without stromal invasion.

　

 

【 Fig. 83-3 (HP)】Severely dysplastic keratinocytes with hyperchromatic and pleomorphic nuclei.