《Slide 83.》Squamous cell carcinoma in situ, Cervix
A. Brief Descriptions:
Human papilloma virus (HPV) is currently considered and important factor in cervical oncogenesis.
Koilocytic atypia: nuclear atypia and perinuclear vacuolization → viral “cytopathic” effect; in the upper and middle lining squamous epithelium.
Dysplasia: mild, moderate and severe.
Cervical intraepithelial neoplasia (CIN): CIN I, II, III.
Squamous intraepithelial lesion (SIL): low-grade and high-grade.
B. Gross Findings:
No significant lesion.
C. Micro Findings:
Full-thickness dysplasia without any differentiation: atypical cells with hyperchromatism, altered polarity, and irregular nuclei in the entire thickness of squamous epithelium.
Basement membrane is intact. No stromal invasion.
Compare with slide 185.
Robbins Pathologic Basis of Disease, 6th ed. P.1049-1051.
【 Fig. 83-1 (LP)】Full-thickness dysplasia of squamous epithelium.
【 Fig. 83-2 (LP)】Altered polarity of the epithelium without stromal invasion.
【 Fig. 83-3 (HP)】Severely dysplastic keratinocytes with hyperchromatic and pleomorphic nuclei.