Slide 83.Squamous cell carcinoma in situ, Cervix

A. Brief Descriptions:

  1. Human papilloma virus (HPV) is currently considered and important factor in cervical oncogenesis.

  2. Koilocytic atypia: nuclear atypia and perinuclear vacuolization viral “cytopathic” effect; in the upper and middle lining squamous epithelium.

  3. Classification:

B. Gross Findings:

    No significant lesion.

C. Micro Findings:

  1. Full-thickness dysplasia without any differentiation: atypical cells with hyperchromatism, altered polarity, and irregular nuclei in the entire thickness of squamous epithelium.

  2. Basement membrane is intact. No stromal invasion.

D. Others:

  1. Compare with slide 185.

E. Reference:

  1. Robbins Pathologic Basis of Disease, 6th ed.  P.1049-1051.




Fig. 83-1 (LP)Full-thickness dysplasia of squamous epithelium.




Fig. 83-2 (LP)Altered polarity of the epithelium without stromal invasion.



Fig. 83-3 (HP)Severely dysplastic keratinocytes with hyperchromatic and pleomorphic nuclei.