《Slide 82.》Thecofibroma, Ovary

A. Brief Descriptions:

  1. Definition:

    These neoplasms arise from the ovarian stroma and exhibit a spectrum of histological appearances that includes, at one end, simple fibromas and , at the other end, tumors showing distinct differentiation to specialized perifollicular or follicular theca cells or their luteinized equivalents.

  2. Clinical profile:

These tumor exhibit a much lower frequency of associated endometrial pathology and evidence of endocrine disturbance then do the 'pure' thecoma.

　

B. Gross Findings:

  1. Unilateral, solid, spherical, or slightly lobulated, encapsulated, hard, gray-white masses covered by glistening intact ovarian serosa.

C. Micro Findings:

  1. Interlacing bands of dense fibrous tissue with well-differentiated fibroblasts (fibroma) separated by hyaline stroma.

  2. These closely packed spindle stromal cells arranged in a feather-striched or storiform pattern.

  3. Some spindle cells with centrally placed nuclei and a moderate amount of pale cytoplasm (lipid) are clusters of thecal cells (thecoma).

D. Others:

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E. Reference:

  1. Robbins Pathologic Basis of Disease, 6th ed.  P.1077-1078.

 

 

【 Fig. 82-1 (LP)】Thecofibroma (right) and ovary.

　

 

 

【 Fig. 82-2 (LP)】Sheets of plump theca cells and attenuated fibroblastic cells (left lower portion).

 

 

 

【 Fig. 82-3 (HP)】Plump, differentiated stromal cells with thecal appearance (bottom) and fibrotic cells (top).