《Slide 82.》Thecofibroma, Ovary
A. Brief Descriptions:
These neoplasms arise from the ovarian stroma and exhibit a spectrum of histological appearances that includes, at one end, simple fibromas and , at the other end, tumors showing distinct differentiation to specialized perifollicular or follicular theca cells or their luteinized equivalents.
These tumor exhibit a much lower frequency of associated endometrial pathology and evidence of endocrine disturbance then do the 'pure' thecoma.
B. Gross Findings:
Unilateral, solid, spherical, or slightly lobulated, encapsulated, hard, gray-white masses covered by glistening intact ovarian serosa.
C. Micro Findings:
Interlacing bands of dense fibrous tissue with well-differentiated fibroblasts (fibroma) separated by hyaline stroma.
These closely packed spindle stromal cells arranged in a feather-striched or storiform pattern.
Some spindle cells with centrally placed nuclei and a moderate amount of pale cytoplasm (lipid) are clusters of thecal cells (thecoma).
Robbins Pathologic Basis of Disease, 6th ed. P.1077-1078.
【 Fig. 82-1 (LP)】Thecofibroma (right) and ovary.
【 Fig. 82-2 (LP)】Sheets of plump theca cells and attenuated fibroblastic cells (left lower portion).
【 Fig. 82-3 (HP)】Plump, differentiated stromal cells with thecal appearance (bottom) and fibrotic cells (top).