《Slide 85.》Phyllodes tumor, Breast

A. Brief Descriptions：

1. Arise from intralobular stroma; previously known as “cystosarcoma phyllodes”.

2. Classification: benign, low-grade malignant and high-grade malignant.

3. Changes suggesting malignant potential: increased cellularity, high mitotic rate, nuclear pleomorphism, stromal overgrowth, and infiltrative borders.

B. Gross Findings：

1.   Well-circumscribed tumors with leaf-like pattern and fleshy appearance.

C. Micro Findings：

1. Leaf-like projection of stroma.

2. Stromal hypercellularity and presence of benign glandular elements.

3. Increased mitotic figures.

D. Others:

1. Compare with slide 84, fibroadenoma of breast.

E. Reference：

1. Robbins Pathologic Basis of Disease, 6^th ed.  P.1103-1104.

 

 

【 Fig. 85-1 (LP)】Circumscribed  tumor with leaf-like projection.

　

 

 

【 Fig. 85-2 (LP)】Leaf-like pattern.Proliferating stroma covered by benign ductal epithelium.

  

 

【 Fig. 85-3 (LP)】Stromal hypercellularity and presence of benign ductal element (right upper).

　

 

【 Fig. 85-4 (HP)】Increased stromal cellularity with mitotic figures.