Slide 86.Intraductal carcinoma, Breast

A. Brief Descriptions

  1. Ductal carcinoma in situ.

  2. Definition: Ductal carcinoma with intact basement membrane.

  3. Five architectural subtypes: comedocarcinoma, solid, cribriform, papillary, and micropapillary.

B. Gross Findings

  1. Poorly defined focus of slightly increased consistency

  2. Punctate areas of necrotic material (comedone-like)

C. Micro Findings

  1. Dilated ducts filled with neoplastic anaplastic epithelial cells that plug lumina.

  2. Presence of central necrosis in some ducts.

  3. Focal cribriform growth pattern.

  4. Tumor cells: loosely cohesive, cytologic atypia, increased mitotic figures.

D. Others:

  1. Compare with slide 87, infiltrating ductal carcinoma of breast.

E. Reference

  1. Robbins Pathologic Basis of Disease, 6th ed.  P.1107-1109.




Fig. 86-1 (LP)Poorly defined tumor mass with focal necrosis.



Fig. 86-2 (LP)Dilated ducts with intact basement membrane and filled with neoplastic epithelial cells.



Fig. 86-3 (LP)Solid pattern.




Fig. 86-4 (LP)Cribriform pattern.




Fig. 86-5 (LP)Comedocarcinoma showing intraductal proliferation of malignant cells with central necrosis.




Fig. 86-6 (HP)The tumor cells showing monomorphic appearance and lacking normal myoepithelial cells.Cellular atypia and loose cohesion are noted.