Slide 87.Infiltrating ductal carcinoma, Breast

A. Brief Descriptions

  1. The largest group of malignant breast tumors.

  2. All carcinomas are thought to arise from the terminal ductlobular unit, and “ductal” and “lobular” no longer imply a site or cell type of origin.

B. Gross Findings

  1. The tumor of stony-hard consistency is retracted and infiltrating the surrounding breast substance.

  2. On cut surface showing radiating through the surrounding parenchyma into the fat (crab-like configuration).

  3. “Chalky streaks” on the cut surface due to duct elastosis.

C. Micro Findings

  1. The tumor can infiltrate the breast tissue.

  2. The tumor cells are arranged in cords, sheets, nests or as individual cells with focal irregular ductal formation.

  3. Densely fibrotic to desmoplastic stroma.

D. Others:

  1. Compare with slide 86, intraductal carcinoma of breast. 

E. Reference

  1. Robbins Pathologic Basis of Disease, 6th ed.  P.1110.



Fig. 87-1 (LP)The tumor cells infiltrate the breast tissue.




Fig. 87-2 (LP)The tumor cells infiltrate in the desmoplastic stroma.



Fig. 87-3 (LP)The tumor cells are arranged in cords with focal ductal formation.




Fig. 87-4 (LP)The tumor cells are infiltrating into the adjacent adipose tissue.




Fig. 87-5 (HP)The tumor cells are pleomorphic and have hyperchromatic nucleus.