Slide 108.Hyaline membrane disease, Lung

A. Brief Descriptions

  1. A consequence of non-specific injury to the bronchiolar and alveolar lining.

  2. Respiratory distress syndrome of new born, always seen in premature infants. (Cause: deficiency of pulmonary surfactiant).

B. Gross Findings

  1. Heavy (because of pulmonary edema ,congestion ), purple and solid appearance of lung.

C. Micro Findings

  1. Pink, fibrin-rich hyaline membranes lining small and collapsed alveolar spaces and necrotic debris mainly within the respiratory bronchioles, alveolar ducts and unopened alveoli.

  2. Hyaline membrane: compacted plasma exudates and cellular debris.

D. Others:


E. Reference

  1. Robbins Pathologic Basis of Disease, 6th ed.  Ch.11.P.471~473.



Fig. 108-1 (LP)




Fig. 108-2 (LP)




Fig. 108-3 (HP)