《Slide 116.》Fulminant hepatitis, Liver

A. Brief Descriptions：

1. From onset of hepatic insufficiency to the symptom of hepatic encephalopathy within 2 to 3 weeks.

2. Viral hepatitis in the main causes.

B. Gross Findings：

1. Acute massive necrosis or acute submassive necrosis.

C. Micro Findings：

1. Panacinar necrosis by：

• extensive hepatocytes loss.

• mixed tubules or neocholangioles: proliferation of duct-like structure around portal tracts, partly of bile-duct & partly of hepatocellular origin.

• inflammatory-cell infiltration, mixed & variable in degree.

• collapse of the reticular framework.

D.Others:

  略.

E.Reference：

1. Robbins Pathologic Basis of Disease, 6^th ed.  P.867.

　

 

【 Fig. 116-1 (LP)】Confluent area of destructed hepatic parenchyma.

　

 

 

【 Fig. 116-2 (LP)】The normal hepatic architecture is nearly totally destructed, accompanied by inflammatory infiltrate and regenerative activity of  hepatocytes.

　

 

【 Fig. 116-3 (HP)】Regenerative activity of remainder hepatocytes showing neocholangioles with ductile-like structure.(left)