《Slide 116.》Fulminant hepatitis, Liver
A. Brief Descriptions：
From onset of hepatic insufficiency to the symptom of hepatic encephalopathy within 2 to 3 weeks.
Viral hepatitis in the main causes.
B. Gross Findings：
Acute massive necrosis or acute submassive necrosis.
C. Micro Findings：
Panacinar necrosis by：
extensive hepatocytes loss.
mixed tubules or neocholangioles: proliferation of duct-like structure around portal tracts, partly of bile-duct & partly of hepatocellular origin.
inflammatory-cell infiltration, mixed & variable in degree.
collapse of the reticular framework.
Robbins Pathologic Basis of Disease, 6th ed. P.867.
【 Fig. 116-1 (LP)】Confluent area of destructed hepatic parenchyma.
【 Fig. 116-2 (LP)】The normal hepatic architecture is nearly totally destructed, accompanied by inflammatory infiltrate and regenerative activity of hepatocytes.
【 Fig. 116-3 (HP)】Regenerative activity of remainder hepatocytes showing neocholangioles with ductile-like structure.(left)