Slide 116.Fulminant hepatitis, Liver

A. Brief Descriptions

  1. From onset of hepatic insufficiency to the symptom of hepatic encephalopathy within 2 to 3 weeks.

  2. Viral hepatitis in the main causes.

B. Gross Findings

  1. Acute massive necrosis or acute submassive necrosis.

C. Micro Findings

  1. Panacinar necrosis by




  1. Robbins Pathologic Basis of Disease, 6th ed.  P.867.



Fig. 116-1 (LP)Confluent area of destructed hepatic parenchyma.




Fig. 116-2 (LP)The normal hepatic architecture is nearly totally destructed, accompanied by inflammatory infiltrate and regenerative activity of  hepatocytes.



Fig. 116-3 (HP)Regenerative activity of remainder hepatocytes showing neocholangioles with ductile-like structure.(left)