Slide 117.Cirrhosis (postnecrotic), Liver

A. Brief Descriptions:

  1. Mainly due to chronic viral hepatitis.

  2. Irregular size of nodules.

B. Gross Findings

  1. Fibrosis, regenerated nodules & complete vascular distortion of the liver.

C. Micro Findings

  1. Nodules of varying size.

  2. Thick or thin fibrous septi.

  3. Inflammatory cells, bile ducts, vessels within the fibrous septi.

D. Others:


E. Reference

  1. Robbins Pathologic Basis of Disease, 6th ed.  P.864~866.




Fig. 117-1 (LP)The entire liver parenchyma is divided into nodules of variable size.




Fig. 117-2 (LP)Dense inflammatory infiltrate in the fibrous septae segregated liver parenchyma.




Fig. 117-3 (LP)Widening and fibrosis of periportal area connecting with each other resulting in nodules formation.  Note dense inflammatory cells infiltrate in fibrotic bands.




Fig. 117-4 (LP)Areas of fatty metamorphosis of hepatocytes are also seen.




Fig. 117-5 (LP)Regeneration nodules showing regenerating atypia of hepatocytes (multinucleation and hyperchromatism).